A new generation of

Immunotherapy

A recipient of FDA's Fast Track designation, Diakonos is a clinical-stage biotechnology company developing a groundbreaking Dendritic Cell Vaccine (DCV) for difficult-to-treat cancers.

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Redefining the Potential of Immunotherapy

Dentritic
Cell Vaccines

Developed at the Texas Medical Center, DOC1021 represents a novel approach to fighting cancer that harnesses the body’s natural anti-viral immune response.

At the core of DOC1021 is Diakonos’ proprietary “double-loading” technique. This patented process tricks the body into perceiving cancer cells as virally infected cells, mirroring the natural detection and elimination process for viral infections.

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Groundbreaking
Discovery on the
Immune System

DOC1021 is based on a discovery on how dendritic cells are able to detect and respond to viral threats. Based on Diakonos’ research, it is now known that dendritic cells compare antigens presented on MHC Class 1 and 2.

When identical antigens are detected on both MHC Class 1 and 2, dendritic cells mobilize formidable CD8 CD161 T cells to destroy what the immune system believes are infected cells throughout the body.

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Diakonos Oncology

News & Media

SNO 2024 Presentation: DOC1021 Cell-Based Vaccination as Adjuvant Therapy for Glioblastoma: Phase I Clinical Trial Analysis

Diakonos Oncology Appoints Laura Aguilar, M.D., Ph.D. as Chief Medical Officer

Company also names Deancy Okoebor Director of Clinical Operations and Eva Highberg Schumann Project Coordinator as it prepares for a Phase 2 trial of its unique dendritic cell vaccine for glioblastoma HOUSTON–(November 18, 2024)–Diakonos Oncology Corp., a clinical stage immuno-oncology company, announced today that Laura Aguilar, M.D., Ph.D., has been appointed Chief Medical Officer. Dr. Aguilar, a […]

SITC 2024 Poster: Vaccination by Homologous Antigenic Loading as Adjuvant Therapy for Glioblastoma: Correlation of Immune Response and Early Efficacy Signal with Vaccine Cell Gene Signature

Clinical Trials

Underway

Discover our treatment centers and find out which one is best for you.

Pancreatic Adenocarcinoma

Baylor College of MedicinePhase 1, NCT04157127

Conducted in partnership with the Baylor College of Medicine, this phase 1, first in man trial is to determine the safety, toxicity, and feasibility of delivering autologous Dendritic Cells (DCs) to Pancreatic Cancer patients as adjuvant therapy following completion of standard chemotherapy.

MD Anderson Cooper, UT Health Science Center<br /> Phase 1, NCT04552886

Glioblastoma

MD Anderson Cooper, UT Health Science Center
Phase 1, NCT04552886

Conducted in partnership with the MD Anderson Cooper Hospital, this is a single arm (non-randomized) first-in-man pilot study to evaluate the safety and feasibility of delivering a Diakonos loaded Dendritic Cell Vaccine in nine to twenty-four adult patients diagnosed with Glioblastoma (GBM) after undergoing neurosurgical tumor resection, and in whom a neuropathological diagnosis has been established.

Sarcoma

MD Anderson
Phase 1, Pending

Conducted in partnership with the MD Anderson, this is a single arm (non-randomized) first-in-man pilot study to evaluate the safety and feasibility of delivering a Diakonos loaded Dendritic Cell Vaccine in nine to twenty-four adult patients diagnosed with Sarcoma after undergoing Standard of Care.

Serving the Patient,
not the Cancer.

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